AN OVERVIEW FOR PHYTOCHEMICAL ACTIVITIES OF CARICA PAPAYA FRUIT
Keywords:
papaya, Carica papaya, anti-fungal, anti-microbial, anti-bacterial, antioxidantAbstract
Papaya, scientifically known as Carica papaya or Carica Papaya Linn is the only edible member of the Caricaceae family. Papaya is a large herbaceous plant exploited for its biological activities. Papaya's wide range of uses and activities are attributed to its abundance of enzymes, minerals, nutrients, and phyto-constituents. Its applications range from adding it to one's diet regularly to treating minor illnesses and even serious conditions like cancer. All of the papaya plant's parts; bark, flowers, fruit, latex, leaves, peel, roots, seeds, and stem have therapeutic and medical uses. The use of papaya as a food and traditional medicine is as old as mankind. Presently, to overcome antibiotic-resistant microbes, C. papaya is a natural source with far more advantages. C. papaya plant is used in commercial, industrial, medicinal, and therapeutic applications owing mainly to its anti-inflammatory, antioxidant, and anti-microbial properties. This review aims to provide a concise review of the applications of C. papaya.
Downloads
References
Abdullah, M., Chai, P.-S., Loh, C.-Y., Chong, M.-Y., Quay, H.-W., Vidyadaran, S., Seman, Z.,Kandiah, M., & Seow, H.-F. (2011). Carica Papaya Increases Regulatory T cells and Reduces IFN-γ+cd4+ T cells in Healthy Human Subjects. Molecular Nutrition & Food Research, 55(5), 803–806. https://doi.org/10.1002/mnfr.201100087
Abdullah, Amin, F., Hassan, N., Bashir, K., Khan, A., Bibi, H., Irshad, M., Khan, S., Nawaz, K., & Ullah, Z. (2023). Antimicrobial susceptibility profile of various bacteria isolated from respiratory tract infection. Bulletin of Biological and Allied Sciences Research, 2023(1), 48. https://doi.org/10.54112/bbasr.v2023i1.48
Abo, K. A., Fred-Jaiyesimi, A. A., & Jaiyesimi, A. E. (2008). Ethnobotanical Studies of Medicinal Plants used in the Management of Diabetes Mellitus in South Western Nigeria. Journal of Ethnopharmacology, 115(1), 67–71. https://doi.org/10.1016/j.jep.2007.09.005
Adesuyi, A. O., & Ipinmoroti, K. O. (2010). The Nutritional and Functional Properties of the Seed Flour of Three Varieties of Carica papaya.Current Research in Chemistry, 3(1), 70–75. https://doi.org/10.3923/crc.2011.70.75
Adiaha MS, Adiaha MS (2017) Effect of Nutritional, Medicinal and
Pharmacological Properties of Papaya (Carica papaya Linn.) to
human development: A review. World Sci News 67:238–249
Adiaha, Monday & Adiaha, Magdalene. (2021). Effect of Nutritional, Medicinal and Pharmacological Properties of Papaya (Carica papaya Linn.) to Human Development: A Review. World Scientific News, 67(2), 238-249.
Ahmad, N., Fazal, H., Ayaz, M., Abbasi, B. H., Mohammad, I., & Fazal, L. (2011). Dengue fever Treatment with Carica papaya Leaves Extracts. Asian Pacific Journal of Tropical Biomedicine, 1(4), 330–333. https://doi.org/10.1016/S2221-1691(11)60055-5
Akindele, A. J., Awodele, O., Alagbaoso, A. A., & Adeyemi, O. O. (2011). Anti-Diarrhoeal Activity of DAS-77 (A Herbal Preparation). Nigerian Quarterly Journal of Hospital Medicine, 21(4), 317–323.
Alabi, O. A., Haruna, M. T., Anokwuru, C. P., Jegede, T., Abia, H., Okegbe, V. U., & Esan, B. E. (2012). Comparative studies on Antimicrobial Properties of Extracts of Fresh and Dried leaves of Carica papaya (L) on Clinical Bacterial and fungal isolates. Advances in Applied Science Research, 3(5), 3107–3114.
Alam, M., Ahmed, S., Elasbali, A. M., Adnan, M., Alam, S., Hassan, M. I., & Pasupuleti, V. R. (2022). Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases. Frontiers in Oncology, 12, 860508. https://doi.org/10.3389/fonc.2022.860508
Alara, O. R., Abdurahman, N. H., & Alara, J. A. (2020). Carica papaya: Comprehensive overview of the nutritional values, phytochemicals and pharmacological activities. Advances in Traditional Medicine, 22(1), 17–47. https://doi.org/10.1007/s13596-020-00481-3
Al-Duais, M., Hohbein, J., Werner, S., Böhm, V., & Jetschke, G. (2009). Contents of vitamin C, carotenoids, tocopherols, and tocotrienols in the subtropical plant species cyphostemma digitatum as affected by processing. Journal of Agricultural and Food Chemistry, 57(12), 5420–5427. https://doi.org/10.1021/jf9003626
Amer, J., Goldfarb, A., Rachmilewitz, E. A., & Fibach, E. (2008). Fermented papaya preparation as redox regulator in Blood Cells ofβ-thalassemic mice and patients. Phytotherapy Research, 22(6), 820–828. https://doi.org/10.1002/ptr.2379
Andersson, S. C., Olsson, M. E., Johansson, E., & Rumpunen, K. (2009). Carotenoids in sea buckthorn (Hippophae rhamnoides L.) Berries during ripening and use of pheophytin a as a maturity marker. Journal of Agricultural and Food Chemistry, 57(1), 250–258. https://doi.org/10.1021/jf802599f
Anjana, G. V., Priya, D., Srimathi, R., & Shantha, B. K. (2018). A review on medical advantages and chemical constituents of Carica papaya Linn. Asian Journal of Pharmaceutical and Clinical Research, 11(9), 53. https://doi.org/10.22159/ajpcr.2018.v11i9.26992
Anuar, N. S., Zahari, S. S., Taib, I. A., & Rahman, M. T. (2008). Effect of Green and Ripe Carica papaya Epicarp extracts on Wound Healing and During Pregnancy. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 46(7), 2384–2389. https://doi.org/10.1016/j.fct.2008.03.025
Araújo, F. S., Carvalho, C. R., & Clarindo, W. R. (2010). Genome size, base composition and karyotype of Carica papaya L. The Nucleus, 53(1-2), 25–31. https://doi.org/10.1007/s13237-010-0007-8
Aravind, G., Bhowmik, D., S.Duraivel, & G.Harish (2013). Traditional and Medicinal Uses of Carica papaya. Journal of Medicinal Plants Studies, 1, 07-15.
Aruoma, O. I., Hayashi, Y., Marotta, F., Mantello, P., Rachmilewitz, E., & Montagnier, L. (2010). Applications and Bio-efficacy of the Functional Food Supplement Fermented Papaya Preparation. Toxicology, 278(1), 6–16. https://doi.org/10.1016/j.tox.2010.09.006
Asmah R, M. A. M. (2014). Proximate analysis, antioxidant and anti proliferative activities of different parts of Carica papaya. Journal of Tissue Science & Engineering, 05(01). https://doi.org/10.4172/2157-7552.1000133
Ayoola, Babatunde & Adeyeye, Adeniyi. (2010). Phytochemical and nutrient evaluation of Carica papaya (Pawpaw) leaves. IJRRAS. 5.
Badillo, V. M., & Leal, F. (2019). Taxonomy and botany of the Caricaceae. Horticultural Reviews, 289–323. https://doi.org/10.1002/9781119625407.ch6
Bajwa, B. & Mazhar, Muhammad & Bashir, M.K. & Honey, S.F.. (2018). Environmental, economic and social impact of biological control interventions in Papaya Farming in Sindh, Pakistan. Pakistan Journal of Life and Social Sciences, 16, 27-34.
Barroso, P. T., de Carvalho, P. P., Rocha, T. B., Pessoa, F. L., Azevedo, D. A., & Mendes, M. F. (2016). Evaluation of the composition of Carica papaya L. seed oil extracted with supercritical CO2. Biotechnology reports (Amsterdam, Netherlands), 11, 110–116. https://doi.org/10.1016/j.btre.2016.08.004
Basalingappa, K. M. (2018). Medicinal uses of Carica papaya. Journal of Natural & Ayurvedic Medicine, 2(6). https://doi.org/10.23880/jonam-16000144
Bashir, M., Farooq, M., Khalid, S., & ALI, Q. (2022). The role of microalgae in different biotechnology applications. Bulletin of Biological and Allied Sciences Research, 2022(1), 25. https://doi.org/10.54112/bbasr.v2022i1.25
Baskaran, C., bai, V. R., Velu, S., & Kumaran, K. (2012). The efficacy of Carica papaya leaf extract on some bacterial and a fungal strain by well diffusion method. Asian Pacific Journal of Tropical Disease, 2. https://doi.org/10.1016/s2222-1808(12)60239-4
Bolu, S. A. O., Sola-Ojo, F. E., Olorunsany, O. A., & Idris, K. (2009). Effect of graded levels of dried pawpaw (carica papaya) seed on the performance, haematology, Serum Biochemistry and carcass evaluation of Chicken Broilers. International Journal of Poultry Science, 8(9), 905–909. https://doi.org/10.3923/ijps.2009.905.909
Brasil, G. A., Ronchi, S. N., do Nascimento, A. M., de Lima, E. M., Romão, W., da Costa, H. B., Scherer, R., Ventura, J. A., Lenz, D., Bissoli, N. S., Endringer, D. C., & de Andrade, T. U. (2014). Antihypertensive Effect of Carica Papaya via a Reduction in ACE Activity and Improved Baroreflex. Planta Medica, 80(17), 1580–1587. https://doi.org/10.1055/s-0034-1383122
Britannica, T. Editors of Encyclopaedia (2021, August 31). Papaya. Encyclopedia Britannica. https://www.britannica.com/plant/papaya
Budama-Kilinc, Y., Cakir-Koc, R., Kecel-Gunduz, S., Zorlu, T., Kokcu, Y., Bicak, B., Karavelioglu, Z., & Ozel, A. E. (2018). Papain Loaded Poly(ε-Caprolactone) Nanoparticles: In-silico and In-Vitro Studies. Journal of Fluorescence, 28(5), 1127–1142. https://doi.org/10.1007/s10895-018-2276-6
Callixte, C., Baptiste, N. J., & Arwati, H. (2020). Phytochemical Screening and Antimicrobial Activities of Methanolic and Aqueous Leaf Extracts of Carica papaya grown in Rwanda. Molecular and Cellular Biomedical Sciences, 4(1), 39. https://doi.org/10.21705/mcbs.v4i1.74
Canini, A., Alesiani, D., D’Arcangelo, G., & Tagliatesta, P. (2007). Gas Chromatography–Mass Spectrometry Analysis of Phenolic Compounds from Carica papaya L. Leaf. Journal of Food Composition and Analysis, 20(7), 584–590. https://doi.org/10.1016/j.jfca.2007.03.009
Cano Sanchez, M., Lancel, S., Boulanger, E., & Neviere, R. (2018). Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review. Antioxidants (Basel, Switzerland), 7(8), 98. https://doi.org/10.3390/antiox7080098
Cantín, C. M., Moreno, M. A., & Gogorcena, Y. (2009). Evaluation of the Antioxidant Capacity, Phenolic Compounds, and Vitamin C Content of Different Peach and Nectarine [ Prunus persica (L.) Batsch] Breeding Progenies. Journal of Agricultural and Food Chemistry, 57(11), 4586–4592. https://doi.org/10.1021/jf900385a
Carneiro, C. E., & Cruz, J. L. (2009). Caracterização Anatômica de órgãos vegetativos do Mamoeiro. Ciência Rural, 39(3), 918–921. https://doi.org/10.1590/s0103-84782009005000011
Carvalho, F. A., & Renner, S. S. (2013). The phylogeny of the Caricaceae. Genetics and Genomics of Papaya, 81–92. https://doi.org/10.1007/978-1-4614-8087-7_5
Carvalho, F. A., & Renner, S. S. (2015). A Dated Phylogeny of the Papaya Family (Caricaceae) reveals the crop’s closest relatives and the family’s biogeographic history §. Molecular Phylogeny, Biogeography and an e-Monograph of the Papaya Family (Caricaceae) as an Example of Taxonomy in the Electronic Age, 49–81. https://doi.org/10.1007/978-3-658-10267-8_4
Chakraborty, M. K., Karmakar, I. Haldar, S.., Nepal, A. U., & Haldar, P. A. (2015). Anticancer And Antioxidant Activity of Methanol Extract of Hippophae Salicifolia in Eac Induced Swiss Albino Mice. International Journal of Pharmacy and Pharmaceutical Sciences, 7(8), 180–184.
Chatterjee, S. (2016). Oxidative Stress, Inflammation and Disease. Oxidative Stress and Biomaterials, 35–58. https://doi.org/10.1016/b978-0-12-803269-5.00002-4
Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2017). Inflammatory Responses and Inflammation-Associated Diseases in Organs. Oncotarget, 9(6), 7204–7218. https://doi.org/10.18632/oncotarget.23208
Collard, E., & Roy, S. (2010). Improved Function of Diabetic Wound-Site Macrophages and Accelerated Wound Closure in Response to Oral Supplementation of a Fermented Papaya Preparation. Antioxidants & Redox Signaling, 13(5), 599–606. https://doi.org/10.1089/ars.2009.3039
Comunian, T., Babazadeh, A., Rehman, A., Shaddel, R., Akbari-Alavijeh, S., Boostani, S., & Jafari, S. M. (2020). Protection and Controlled Release of Vitamin C by Different Micro/Nanocarriers. Critical Reviews in Food Science and Nutrition, 62(12), 3301–3322. https://doi.org/10.1080/10408398.2020.1865258
Corral-Aguayo, R. D., Yahia, E. M., Carrillo-Lopez, A., & González-Aguilar, G. (2008). Correlation between some Nutritional Components and the total Antioxidant Capacity measured with Six Different Assays in Eight Horticultural Crops. Journal of Agricultural and Food Chemistry, 56(22), 10498–10504. https://doi.org/10.1021/jf801983r
Da Cunha, F. M., Duma, D., Assreuy, J., Buzzi, F. C., Niero, R., Campos, M. M., & Calixto, J. B. (2004). Caffeic Acid Derivatives: In vitro and in vivo Anti-Inflammatory Properties. Free Radical Research, 38(11), 1241–1253. https://doi.org/10.1080/10715760400016139
Dash, B. P., Archana, Y., Satapathy, N., & Naik, S. K. (2013). Search for Antisickling Agents from Plants. Pharmacognosy Reviews, 7(13), 53–60. https://doi.org/10.4103/0973-7847.112849
Din, S., Fazal, M., Ishtiaque, A., & Ullah, A. (2023). Antimicrobial activity of lantana camara against pseudomonas aeruginosa, serratia marcescens and staphylococcus aureus to develop ointment based therapy. Bulletin of Biological and Allied Sciences Research, 2023(1), 33. https://doi.org/10.54112/bbasr.v2023i1.33
Doughari, J.H., Elmahmood, A.M., and Manzara, S. (2007).
Studies on the antibacterial activity of root extracts of
Carica papaya L. African Journal of Microbiology
Research, 1(3):37–41
Druesne-Pecollo, N., Latino-Martel, P., Norat, T., Barrandon, E., Bertrais, S., Galan, P., & Hercberg, S. (2010). Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. International Journal of Cancer, 127(1), 172–184. https://doi.org/10.1002/ijc.25008
Dwivedi, M. K., Sonter, S., Mishra, S., Patel, D. K., & Singh, P. K. (2020). Antioxidant, antibacterial activity, and phytochemical characterization of Carica Papaya Flowers. Beni-Suef University Journal of Basic and Applied Sciences, 9(1). https://doi.org/10.1186/s43088-020-00048-w
Evans, E. A., & Ballen, F. H. (2012). An Overview of Global Papaya Production, Trade and Consumption. FE913/FE913: An Overview of Global Papaya Production, Trade, and Consumption. Retrieved June 8, 2022, from https://edis.ifas.ufl.edu/publication/FE913
Ezike, A. C., Akah, P. A., Okoli, C. O., Ezeuchenne, N. A., & Ezeugwu, S. (2009). Carica papaya (Paw-Paw) Unripe Fruit may be bBeneficial in Ulcer. Journal of Medicinal Food, 12(6), 1268–1273. https://doi.org/10.1089/jmf.2008.0197
Fabi, J. P., & do Prado, S. B. (2019). Fast and furious: Ethylene-triggered changes in the metabolism of papaya fruit during ripening. Frontiers in Plant Science, 10. https://doi.org/10.3389/fpls.2019.00535
Fabi, J. P., Seymour, G. B., Graham, N. S., Broadley, M. R., May, S. T., Lajolo, F. M., Cordenunsi, B. R., & Oliveira do Nascimento, J. R. (2012). Analysis of Ripening-Related Gene Expression in Papaya using an Arabidopsis-Based Microarray. BMC Plant Biology, 12(1). https://doi.org/10.1186/1471-2229-12-242
Farrag FH, Refaey MM, Khalil F, Mehrim A (2014) Pawpaw (Carica
papaya) seeds powder in Nile Tilapia (Oreochromis niloticus)
diet 1-growth performance, survival, feed utilization, carcass
composition of fry and fingerlings tilapia (Oreochromis niloticus) diet utilization, carcass composition. Journal of Animal Poultry Production, 4:363–379
Fibach, E., & Rachmilewitz, E. A. (2010). The Role of Antioxidants and Iron Chelators in the Treatment of Oxidative Stress in Thalassemia. Annals of the New York Academy of Sciences, 1202, 10–16. https://doi.org/10.1111/j.1749-6632.2010.05577.x
García-Solís, P., Yahia, E. M., Morales-Tlalpan, V., & Díaz-Muñoz, M. (2009). Screening of Antiproliferative Effect of Aqueous Extracts of Plant Foods Consumed in México on the Breast Cancer Cell Line MCF-7. International Journal of Food Sciences and Nutrition, 60 Suppl 6, 32–46. https://doi.org/10.1080/09637480802312922
Gayosso-García Sancho, L. E., Yahia, E. M., & González-Aguilar, G. A. (2011). Identification and quantification of phenols, carotenoids, and vitamin C from papaya (Carica papaya L., CV. Maradol) fruit determined by HPLC-Dad-MS/MS-ESI. Food Research International, 44(5), 1284–1291. https://doi.org/10.1016/j.foodres.2010.12.001
Gayosso-García Sancho, L. E., Yahia, E. M., & González-Aguilar, G. A. (2013). Contribution of Major Hydrophilic and Lipophilic Antioxidants from Papaya Fruit to Total Antioxidant Capacity. Food and Nutrition Sciences, 04(08), 93–100. https://doi.org/10.4236/fns.2013.48a012
Gbolade A. A. (2009). Inventory of Antidiabetic Plants in Selected Districts of Lagos State, Nigeria. Journal of Ethnopharmacology, 121(1), 135–139. https://doi.org/10.1016/j.jep.2008.10.013
Gella, A., & Durany, N. (2009). Oxidative Stress in Alzheimer Disease. Cell adhesion & Migration, 3(1), 88–93. https://doi.org/10.4161/cam.3.1.7402
Genestra M. (2007). Oxyl Radicals, Redox-Sensitive Signalling Cascades and Antioxidants. Cellular Signalling, 19(9), 1807–1819. https://doi.org/10.1016/j.cellsig.2007.04.009
Ghosh, S., Saha, M., Bandyopadhyay, P. K., & Jana, M. (2017). Extraction, Isolation and Characterization of Bioactive Compounds from Chloroform Extract of Carica papaya Seed and it's In Vivo Antibacterial Potentiality in Channa punctatus against Klebsiella PKBSG14. Microbial Pathogenesis, 111, 508–518. https://doi.org/10.1016/j.micpath.2017.08.033
Gonzalez, A. C., Costa, T. F., Andrade, Z. A., & Medrado, A. R. (2016). Wound healing - A literature review. Anais brasileiros de dermatologia, 91(5), 614–620. https://doi.org/10.1590/abd1806-4841.20164741
Goo, Y. A., Li, Z., Pajkovic, N., Shaffer, S., Taylor, G., Chen, J., Campbell, D., Arnstein, L., Goodlett, D. R., & van Breemen, R. B. (2007). Systematic Investigation of Lycopene Effects in LNCaP Cells by use of Novel Large-scale Proteomic Analysis Software. Proteomics. Clinical Applications, 1(5), 513–523. https://doi.org/10.1002/prca.200600511
Gorinstein, S., Park, Y.-S., Heo, B.-G., Namiesnik, J., Leontowicz, H., Leontowicz, M., Ham, K.-S., Cho, J.-Y., & Kang, S.-G. (2009). A Comparative Study of Phenolic Compounds and Antioxidant and Antiproliferative Activities in frequently consumed raw Vegetables. European Food Research and Technology, 228(6), 903–911. https://doi.org/10.1007/s00217-008-1003-y
Gülçin İ. (2012). Antioxidant Activity of Food Constituents: An Overview. Archives of Toxicology, 86(3), 345–391. https://doi.org/10.1007/s00204-011-0774-2
Guo, S., & Dipietro, L. A. (2010). Factors Affecting Wound Healing. Journal of Dental Research, 89(3), 219–229. https://doi.org/10.1177/0022034509359125
Hamid, M., Bashir, K., Rizwan, M., Khilgee, F., Aamir, M., & Khayam, K. (2023). Phenotypic determination of inducible clindamycin resistant and methicillin resistant staphylococcus aureus from clinical isolates of Khyber Teaching Hospital, Peshawar. Bulletin of Biological and Allied Sciences Research, 2023(1), 41. https://doi.org/10.54112/bbasr.v2023i1.41
Haque, M. A. (2004). Chromosome Identification in Papaya (Carica papaya). Journal of Bangladesh Agricultural University, 2(1), 25–30.
Highfield J. (2009). Diagnosis and Classification of Periodontal Disease. Australian Dental Journal, 54 Suppl 1, S11–S26. https://doi.org/10.1111/j.1834-7819.2009.01140.x
Hounsome, N., Hounsome, B., Tomos, D., & Edwards-Jones, G. (2008). Plant Metabolites and Nutritional Quality of Vegetables. Journal of Food Science, 73(4), R48–R65. https://doi.org/10.1111/j.1750-3841.2008.00716.x
Hussain, T., Tan, B., Yin, Y., Blachier, F., Tossou, M. C., & Rahu, N. (2016). Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?. Oxidative Medicine and Cellular Longevity, 2016, 7432797. https://doi.org/10.1155/2016/7432797
Ikram, E. H., Stanley, R., Netzel, M., & Fanning, K. (2015). Phytochemicals of Papaya and its Traditional Health and Culinary Uses –A Review. Journal of Food Composition and Analysis, 41, 201–211. https://doi.org/10.1016/j.jfca.2015.02.010
Itagaki, S., Kurokawa, T., Nakata, C., Saito, Y., Oikawa, S., KobayashI, M., Hirano, T., & Iseki, K. (2009). In vitro and in vivo Antioxidant Properties of Ferulic Acid: A Comparative Study with other Natural Oxidation Inhibitors. Food Chemistry, 114(2), 466–471. https://doi.org/10.1016/j.foodchem.2008.09.073
Jaikang , C., & Chaiyasut, C. (2010). Caffeic Acid and its Derivatives as Heme-oxygenase 1 Inducer in Hep G2 Cell Line. Journal of Medicinal Plants Research, 4(10), 940–946. https://doi.org/ 10.5897/JMPR10.129
Janis, J. E., & Harrison, B. (2016). Wound Healing: Part I. Basic Science. Plastic and Reconstructive Surgery, 138(3 Suppl), 9S–17S. https://doi.org/10.1097/PRS.0000000000002773
Jarisarapurin, W., Sanrattana, W., Chularojmontri, L., Kunchana, K., & Wattanapitayakul, S. K. (2019). Antioxidant Properties of Unripe Carica papaya Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress. Evidence-based Complementary and Alternative Medicine: eCAM, 2019, 4912631. https://doi.org/10.1155/2019/4912631
Jayasinghe, C. D., Gunasekera, D. S., De Silva, N., Jayawardena, K., & Udagama, P. V. (2017). Mature Leaf Concentrate of Sri Lankan Wild Type Carica papaya Linn. Modulates Nonfunctional and Functional Immune Responses of Rats. BMC Complementary and Alternative Medicine, 17(1), 230. https://doi.org/10.1186/s12906-017-1742-z
Jiménez, V. M., Mora-Newcomer, E., & Gutiérrez-Soto, M. V. (2013). Biology of the papaya plant. Genetics and Genomics of Papaya, 17–33. https://doi.org/10.1007/978-1-4614-8087-7_2
Juárez-Rojop, I. E., Díaz-Zagoya, J. C., Ble-Castillo, J. L., Miranda-Osorio, P. H., Castell-Rodríguez, A. E., Tovilla-Zárate, C. A., Rodríguez-Hernández, A., Aguilar-Mariscal, H., Ramón-Frías, T., & Bermúdez-Ocaña, D. Y. (2012). Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats. BMC complementary and alternative medicine, 12, 236. https://doi.org/10.1186/1472-6882-12-236
Kanda, Y., Osaki, M., & Okada, F. (2017). Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction. International Journal of Molecular Sciences, 18(4), 867. https://doi.org/10.3390/ijms18040867
Kapoor, S., & Saraf, S. (2011). Topical herbal therapies an alternative and complementary choice to combat acne. Research Journal of Medicinal Plant, 5(6), 650–669. https://doi.org/10.3923/rjmp.2011.650.669
Kapoor, S., 2009. Flavours of the Orient. Popular Prakashan, Bhulabai Desai, Mumbai, India
Kharaeva, Z. F., Zhanimova, L. R., Mustafaev, M. S., De Luca, C., Mayer, W., Chung Sheun Thai, J., Tiew Siok Tuan, R., & Korkina, L. G. (2016). Effects of standardised fermented papaya gel on clinical symptoms, inflammatory cytokines, and nitric oxide metabolites in patients with chronic periodontitis: An open randomised clinical study. Mediators of Inflammation, 2016, 1–12. https://doi.org/10.1155/2016/9379840
Khaw, K.-Y., Shaw, P. N., Parat, M.-O., Pandey, S., & Falconer, J. R. (2020). Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice. Processes, 8(5), 610. https://doi.org/10.3390/pr8050610
Khor, B.-K., Chear, N. J.-Y., Azizi, J., & Khaw, K.-Y. (2021). Chemical composition, antioxidant and cytoprotective potentials of Carica papaya leaf extracts: A comparison of supercritical fluid and conventional extraction methods. Molecules, 26(5), 1489. https://doi.org/10.3390/molecules26051489
Kong, Y. R., Jong, Y. X., Balakrishnan, M., Bok, Z. K., Weng, J., Tay, K. C., Goh, B. H., Ong, Y. S., Chan, K. G., Lee, L. H., & Khaw, K. Y. (2021). Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review. Biology, 10(4), 287. https://doi.org/10.3390/biology10040287
Kovendan, K., Murugan, K., Panneerselvam, C., Aarthi, N., Kumar, P. M., Subramaniam, J., Amerasan, D., Kalimuthu, K., & Vincent, S. (2012). Antimalarial Activity of Carica papaya (family: Caricaceae) leaf extract against Plasmodium falciparum. Asian Pacific Journal of Tropical Disease, 2. https://doi.org/10.1016/s2222-1808(12)60171-6
Krishna, K. L., Paridhavi, M., & Patel, J. A. (2008). Review on nutritional, medicinal and pharmacological properties of Papaya (Carica papaya Linn.). Natural Product Radiance, 7(4), 364–373.
Leal-Costa, M. V., Munhoz, M., Meissner Filho, P. E., Reinert, F., & Tavares, E. S. (2010). Anatomia foliar de Plantas transgênicas e não transgênicas de carica papaya L. (Caricaceae). Acta Botanica Brasilica, 24(2), 595–597. https://doi.org/10.1590/s0102-33062010000200030
Leisegang K. (2022). Oxidative Stress in Men with Obesity, Metabolic Syndrome and Type 2 Diabetes Mellitus: Mechanisms and Management of Reproductive Dysfunction. Advances in Experimental Medicine and Biology, 1358, 237–256. https://doi.org/10.1007/978-3-030-89340-8_11
Leitão, M., Ribeiro, T., García, P. A., Barreiros, L., & Correia, P. (2022). Benefits of Fermented Papaya in Human Health. Foods (Basel, Switzerland), 11(4), 563. https://doi.org/10.3390/foods11040563
Lephart, E. D. (2016). Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms. Ageing Research Reviews, 31, 36–54. https://doi.org/10.1016/j.arr.2016.08.001
Liu, Z., Moore, P. H., Ma, H., Ackerman, C. M., Ragiba, M., Yu, Q., Pearl, H. M., Kim, M. S., Charlton, J. W., Stiles, J. I., Zee, F. T., Paterson, A. H., & Ming, R. (2004). A Primitive Y Chromosome in Papaya marks incipient Sex Chromosome Evolution. Nature, 427(6972), 348–352. https://doi.org/10.1038/nature02228
Loh, S. P., & Hadira, O. (2011). In Vitro Inhibitory Potential of Selected Malaysian Plants Against Key Enzymes involved in Hyperglycemia and Hypertension. Malaysian Journal of Nutrition, 17(1), 77–86.
Lohidas, J. & Manjusha, S. & Jothi, G.. (2015). Antimicrobial activities of Carica papaya L. Plant Archives 15 (2), 1179-1186.
Mahattanatawee, K., Manthey, J. A., Luzio, G., Talcott, S. T., Goodner, K., & Baldwin, E. A. (2006). Total Antioxidant Activity and Fiber Content of select Florida-grown Tropical Fruits. Journal of Agricultural and Food Chemistry, 54(19), 7355–7363. https://doi.org/10.1021/jf060566s
Maisarah, AM., Nurul, AB., Asmah, R and Fauziah, O. (2013). Antioxidant Analysis of different part of Carica papaya. International Food Research Journal. 1043-1048.
Maniyar, Y., & Bhixavatimath, P. (2012). Antihyperglycemic and Hypolipidemic Activities of Aqueous Extract of Carica papaya Linn. Leaves in Alloxan-induced DIabetic Rats. Journal of Ayurveda and Integrative Medicine, 3(2), 70–74. https://doi.org/10.4103/0975-9476.96519
Masaki H. (2010). Role of Antioxidants in the Skin: Anti-Aging Effects. Journal of Dermatological Science, 58(2), 85–90. https://doi.org/10.1016/j.jdermsci.2010.03.003
Mein, J. R., Lian, F., & Wang, X. D. (2008). Biological activity of lycopene metabolites: implications for cancer prevention. Nutrition reviews, 66(12), 667–683. https://doi.org/10.1111/j.1753-4887.2008.00120.x
Memudu, A. E., & Oluwole, T. J. (2021). The Contraceptive Potential of Carica papaya Seed on Oestrus Cycle, Progesterone, and Histomorphology of the Utero-ovarian Tissue of Adult Wistar Rats. JBRA Assisted Reproduction, 25(1), 34–43. https://doi.org/10.5935/1518-0557.20200023
Ming, R., Yu, Q., & Moore, P. H. (2007). Sex Determination in Papaya. Seminars in Cell & Developmental Biology, 18(3), 401–408. https://doi.org/10.1016/j.semcdb.2006.11.013
Morgan, M. J., & Liu, Z. G. (2011). Crosstalk of Reactive Oxygen Species and NF-κB Signaling. Cell Research, 21(1), 103–115. https://doi.org/10.1038/cr.2010.178
Morton, J.F., 1987. Fruits of Warm Climates. Creative Resources, Inc., Winterville, USA. 336-346
Murakami, S., Eikawa, S., Kaya, S., Imao, M., & Aji, T. (2016). AntiTumor and Immunoregulatory Effects of Fermented Papaya Preparation (FPP: SAIDOPS501). Asian Pacific Journal of Cancer Prevention: APJCP, 17(7), 3077–3084.
Nafiu, A. B., & Rahman, M. T. (2015). Anti-inflammatory and Antioxidant Properties of Unripe Papaya Extract in an Excision Wound Model. Pharmaceutical Biology, 53(5), 662–671. https://doi.org/10.3109/13880209.2014.936470
Nafiu, A. B., Alli-Oluwafuyi, A.-musawwir, Haleemat, A., Olalekan, I. S., & Rahman, M. T. (2019). Papaya (Carica papaya L., Pawpaw). Nonvitamin and Nonmineral Nutritional Supplements, 335–359. https://doi.org/10.1016/b978-0-12-812491-8.00048-5
Nakasone, H.Y., Paull, R.E., 1998. Tropical Fruits. CAB International, Oxford, UK. 443
Nariya, A., & Jhala, D. (2017). Pharmacognostic Study of Carica papaya Leaf Extract as Inhibitors of reactive oxygen species. International Research Journal of Pharmacy, 8(3), 13–17. https://doi.org/10.7897/2230-8407.080328
Nayak, B. S., Anderson, M., & Pinto Pereira, L. M. (2007). Evaluation of Wound-Healing Potential of Catharanthus roseus Leaf Extract in Rats. Fitoterapia, 78(7-8), 540–544. https://doi.org/10.1016/j.fitote.2007.06.008
Niklas, K. J., & Marler, T. E. (2007). Carica papaya (Caricaceae): A Case Study into the Effects of Domestication on Plant Vegetative Growth and Reproduction. American Journal of Botany, 94(6), 999–1002. https://doi.org/10.3732/ajb.94.6.999
Nourazarian, A. R., Kangari, P., & Salmaninejad, A. (2014). Roles of Oxidative Stress in the Development and Progression of Breast Cancer. Asian Pacific Journal of Cancer Prevention : APJCP, 15(12), 4745–4751. https://doi.org/10.7314/apjcp.2014.15.12.4745
Nurain, I. O., Bewaji, C. O., Johnson, J. S., Davenport, R. D., & Zhang, Y. (2017). Potential of Three Ethnomedicinal Plants as Antisickling Agents. Molecular Pharmaceutics, 14(1), 172–182. https://doi.org/10.1021/acs.molpharmaceut.6b00767
Oboh, G., Olabiyi, A. A., Akinyemi, A. J., & Ademiluyi, A. O. (2014). Inhibition of Key Enzymes Linked to Type 2 Diabetes and Sodium Nitroprusside-Induced Lipid Peroxidation in Rat Pancreas by Water-extractable Phytochemicals from Unripe Pawpaw Fruit (Carica papaya). Journal of Basic and Clinical Physiology and Pharmacology, 25(1), 21–34. https://doi.org/10.1515/jbcpp-2013-0002
Od-Ek, P., Deenin, W., Malakul, W., Phoungpetchara, I., & Tunsophon, S. (2020). Anti-obesity Effect of Carica papaya in High-fat Diet Fed Rats. Biomedical Reports, 13(4), 30. https://doi.org/10.3892/br.2020.1337
Odriozola-Serrano, I., Soliva-Fortuny, R., & Martín-Belloso, O. (2008). Phenolic acids, flavonoids, vitamin C and antioxidant capacity of strawberry juices processed by high-intensity pulsed electric fields or heat treatments. European Food Research and Technology, 228(2), 239–248. https://doi.org/10.1007/s00217-008-0928-5
Oloyede, O. I. (2005). Chemical profile of unripe pulp of Carica papaya. Pakistan Journal of Nutrition, 4(6), 379–381. https://doi.org/10.3923/pjn.2005.379.381
Onaku, L. O., Attama, A. A., Okore, V. C., Tijani, A. Y., Ngene, A. A., & Esimone, C. O. (2011). Antagonistic Antimalarial Properties of Pawpaw Leaf Aqueous Extract in Combination with Artesunic Acid in Plasmodium Berghei-Infected Mice. Journal of Vector Borne Diseases, 48(2), 96–100.
Otsuki, N., Dang, N. H., Kumagai, E., Kondo, A., Iwata, S., & Morimoto, C. (2010). Aqueous Extract of Carica papayaLeaves Exhibits Antitumor Activity and Immunomodulatory Effects. Journal of Ethnopharmacology, 127(3), 760–767. https://doi.org/10.1016/j.jep.2009.11.024
Pandey, S., Cabot, P. J., Shaw, P. N., & Hewavitharana, A. K. (2016). Anti-inflammatory and Immunomodulatory Properties of Carica papaya. Journal of Immunotoxicology, 13(4), 590–602. https://doi.org/10.3109/1547691x.2016.1149528
Panzarini, E., Dwikat, M., Mariano, S., Vergallo, C., & Dini, L. (2014). Administration Dependent Antioxidant Effect of Carica papaya Seeds Water Extract. Evidence-based Complementary and Alternative Medicine: eCAM, 2014, 281508. https://doi.org/10.1155/2014/281508
Park, M. J., & Bae, Y. S. (2016). Fermented Acanthopanax koreanum Root Extract Reduces UVB- and H2O2-Induced Senescence in Human Skin Fibroblast Cells. Journal of Microbiology and Biotechnology, 26(7), 1224–1233. https://doi.org/10.4014/jmb.1602.02049
Parle, Milind & Gurditta, (2011). Basketful Benefits of Papaya. International Research Journal of Pharmacy, 2 (7), 6-12.
Pathak, N., Khan, S., Bhargava, A., Raghuram, G. V., Jain, D., Panwar, H., Samarth, R. M., Jain, S. K., Maudar, K. K., Mishra, D. K., & Mishra, P. K. (2014). Cancer Chemopreventive Effects of the Flavonoid-Rich Fraction Isolated from Papaya Seeds. Nutrition and Cancer, 66(5), 857–871. https://doi.org/10.1080/01635581.2014.904912
Pereira, T., de Almeida, P. S., de Azevedo, I. G., da Cunha, M., de Oliveira, J. G., da Silva, M. G., & Vargas, H. (2009). Gas Diffusion in ‘Golden’ Papaya Fruit at Different Maturity Stages. Postharvest Biology and Technology, 54(3), 123–130. https://doi.org/10.1016/j.postharvbio.2009.07.010
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017). Oxidative Stress: Harms and Benefits for Human Health. Oxidative Medicine and Cellular Longevity, 2017, 8416763. https://doi.org/10.1155/2017/8416763
Posse RP, Sousa EF, Bernardo S, Pereira MG, Gottardo RD (2009) Total Leaf Area of Papaya Trees Estimated by a Nondestructive Method. Scientia Agricola 66:462–466
Prabhu, A.K., Devadas, S.M., Lobo, R., Udupa, P., Chawla, K., Ballal, M., 2017.
Antidiarrheal activity and phytochemical analysis of Carica papaya fruit extract. Journal of Pharmaceutical Sciences. 9, 1151–1155.
Praveena P, Jethinlalkhosh JP, Doss VA. (2017) Pharmacological Evaluation
of Antineoplastic Activity of Hydroethanolic Extract of Unripe Fruit
of Carica papaya Linn Using Animal Model. Asian Journal of Pharmaceutical and Clinical Research.10:179-81.
Raffaelli, F., Nanetti, L., Montecchiani, G., Borroni, F., Salvolini, E., Faloia, E., Ferretti, G., Mazzanti, L., & Vignini, A. (2015). In Vitro Effects of Fermented Papaya (Carica papaya, L.) on Platelets Obtained from Patients with Type 2 Diabetes. Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, 25(2), 224–229. https://doi.org/10.1016/j.numecd.2014.10.013
Ranasinghe, P., Ranasinghe, P., Abeysekera, W. P., Premakumara, G. A., Perera, Y. S., Gurugama, P., & Gunatilake, S. B. (2012). In Vitro Erythrocyte Membrane Stabilization Properties of Carica papaya L. Leaf Extracts. Pharmacognosy Research, 4(4), 196–202. https://doi.org/10.4103/0974-8490.102261
Reddy, V. K., Sreeramulu, D., & Raghunath, M. (2010). Antioxidant Activity of Fresh and Dry Fruits Commonly Consumed in India. Food Research International, 43(1), 285–288. https://doi.org/10.1016/j.foodres.2009.10.006
Rinnerthaler, M., Bischof, J., Streubel, M. K., Trost, A., & Richter, K. (2015). Oxidative Stress in Aging Human Skin. Biomolecules, 5(2), 545–589. https://doi.org/10.3390/biom5020545
Rivera-Pastrana, D. M., Yahia, E. M., & González-Aguilar, G. A. (2010). Phenolic and carotenoid profiles of papaya fruit (Carica papaya L.) and their contents under low temperature storage. Journal of the Science of Food and Agriculture, 90(14), 2358–2365. https://doi.org/10.1002/jsfa.4092
Robinson, S., Parigoris, E., Chang, J., Hecker, L., & Takayama, S. (2022). Contracting Scars from Fibrin Drops. Integrative Biology: Quantitative Biosciences from Nano to Macro, 14(1), 1–12. https://doi.org/10.1093/intbio/zyac001
Rockinger, A., Sousa, A., Carvalho, F. A., & Renner, S. S. (2016). Chromosome Number Reduction in the Sister Clade of Carica papaya with Concomitant Genome Size Doubling. American Journal of Botany, 103(6), 1082–1088. https://doi.org/10.3732/ajb.1600134
Rodríguez, L., Plaza, A., Méndez, D., Carrasco, B., Tellería, F., Palomo, I., & Fuentes, E. (2022). Antioxidant Capacity and Antiplatelet Activity of Aqueous Extracts of Common Bean (Phaseolus vulgaris L.) Obtained with Microwave and Ultrasound Assisted Extraction. Plants (Basel, Switzerland), 11(9), 1179. https://doi.org/10.3390/plants11091179
Sadeque, M. Z., Begum, Z. A., Umar, B. U., Ferdous, A. H., Sultana, S., Uddin, M. K., & Uddin, M. K. (2012). Comparative Efficacy of Dried Fruits of Carica papaya Linn. and Vitamin-E on Preventing Hepatotoxicity in Rats. Faridpur Medical College Journal, 7(1), 29–32. https://doi.org/10.3329/fmcj.v7i1.10295
Saeed, F., Arshad, M. U., Pasha, I., Naz, R., Batool, R., Khan, A. A., Nasir, M. A., & Shafique, B. (2014). Nutritional and Phyto-therapeutic potential of papaya (Carica papaya Linn.): An Overview. International Journal of Food Properties, 17(7), 1637–1653. https://doi.org/10.1080/10942912.2012.709210
Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G. M., Dayem, A. A., & Cho, S. G. (2017). Correlation between Oxidative Stress, Nutrition, and Cancer Initiation. International Journal of Molecular Sciences, 18(7), 1544. https://doi.org/10.3390/ijms18071544
Saliasi, I., Llodra, J. C., Bravo, M., Tramini, P., Dussart, C., Viennot, S., & Carrouel, F. (2018). Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial. International Journal of Environmental Research and Public Health, 15(12), 2660. https://doi.org/10.3390/ijerph15122660
Sami, A., Haider, M., Imran, M., Abbas, A., & Javed, M. (2023). Synergizing food safety, quality and genetic improvement: the intersection of food microbiology and processing. Bulletin of Biological and Allied Sciences Research, 2023(1), 44. https://doi.org/10.54112/bbasr.v2023i1.44
Sanchez, B., Li, L., Dulong, J., Aimond, G., Lamartine, J., Liu, G., & Sigaudo-Roussel, D. (2019). Impact of Human Dermal Microvascular Endothelial Cells on Primary Dermal Fibroblasts in Response to Inflammatory Stress. Frontiers in Cell and Developmental Biology, 7, 44. https://doi.org/10.3389/fcell.2019.00044
Sancho, L. E., Yahia, E. M., García-Solís, P., & González-Aguilar, G. A. (2014). Inhibition of Proliferation of Breast Cancer Cells MCF7 and MDA-MB-231 by Lipophilic Extracts of Papaya (Carica papaya L. Var. Maradol) Fruit. Food and Nutrition Sciences, 05(21), 2097–2103. https://doi.org/10.4236/fns.2014.521222
Santana, L. F., Inada, A. C., Espirito Santo, B., Filiú, W., Pott, A., Alves, F. M., Guimarães, R., Freitas, K. C., & Hiane, P. A. (2019). Nutraceutical Potential of Carica papaya in Metabolic Syndrome. Nutrients, 11(7), 1608. https://doi.org/10.3390/nu11071608
Saran, P. L., & Choudhary, R. (2013). Drug Bioavailability and Traditional Medicaments of Commercially Available Papaya: A Review. African Journal of Agricultural Research, 8(25), 3216–3223. https://doi.org/10.5897/AJAR2013.7295
Saravanasingh, D. K., Ramamurthy, D. M., & Parthiban, D. P. (2016). Analysis of Phytochemical Constituents and Antimicrobial Activity of Carica papaya. International Journal of Advanced Research in Biological Sciences, 3(2), 329–334.
Sasidharan, S., Sumathi, V., Jegathambigai, N. R., & Latha, L. Y. (2011). Antihyperglycaemic effects of ethanol extracts of Carica papaya and Pandanus amaryfollius leaf in streptozotocin-induced diabetic mice. Natural product research, 25(20), 1982–1987. https://doi.org/10.1080/14786419.2010.523703
Sasirekha, S., Paul, I. J., & Swamynathan, S. (2018). An API Centric Smart Kitchen Application. 2018 International Conference on Computer, Communication, and Signal Processing (ICCCSP). https://doi.org/10.1109/icccsp.2018.8452850
Schweiggert, R. M., Steingass, C. B., Heller, A., Esquivel, P., & Carle, R. (2011). Characterization of chromoplasts and carotenoids of red- and yellow-fleshed papaya (Carica papaya L.). Planta, 234(5), 1031–1044. https://doi.org/10.1007/s00425-011-1457-1
Sen, C. K., & Roy, S. (2008). Redox Signals in Wound Healing. Biochimica et biophysica acta, 1780(11), 1348–1361. https://doi.org/10.1016/j.bbagen.2008.01.006
Sharma, A., Bachheti, A., Sharma, P., Bachheti, R. K., & Husen, A. (2020). Phytochemistry, pharmacological activities, nanoparticle fabrication, commercial products and waste utilization of Carica papaya L.: A comprehensive review. Current Research in Biotechnology, 2, 145–160. https://doi.org/10.1016/j.crbiot.2020.11.001
Shelke, M., Tamboli, A., Sonawane, P., Sadaphal, P., & Mankar, S. D. (2021). A Review on Pharmacognosy and Pharmacological Activity of Carica papaya Leaf. Research Journal of Pharmacognosy and Phytochemistry, 200–204. https://doi.org/10.52711/0975-4385.2021.00035
Siddique, O., Sundus, A., & Ibrahim, M. F. (2014). Effects of Papaya Leaves on Thrombocyte Counts in Dengue—A Case report. JPMA. The Journal of the Pakistan Medical Association, 64(3), 364–366.
Sies H. (2015). Oxidative Stress: A Concept in Redox Biology and Medicine. Redox Biology, 4, 180–183. https://doi.org/10.1016/j.redox.2015.01.002
Silva, C. R., Oliveira, M. B., Motta, E. S., de Almeida, G. S., Varanda, L. L., de Pádula, M., Leitão, A. C., & Caldeira-de-Araújo, A. (2010). Genotoxic and Cytotoxic Safety Evaluation of Papain (Carica papaya L.) Using In Vitro Assays. Journal of Biomedicine & Biotechnology, 2010, 197898. https://doi.org/10.1155/2010/197898
Silva, J. A. T. da, Rashid, Z., Nhu, D. T., Sivakumar, D., Gera, A., Souza Jr, M. T. eixeira, & Tennant, P. F. (2007). Papaya (Carica papaya L.) Biology and Biotechnology. Tree and Forestry Science and Biotechnology, 1(1), 47-73
Singh, A., Jaiswal, J., Yadav, R., Gupta, S., Mishra, S., & Singh, A. K. (2014). In Vitro Antimicrobial Activity of Medicinal Plants Ashwagandha (Withania Somnifera) and Papaya (Carica papaya) with Commercial Antibiotics. Discovery, 20 (63), 59-64.
Singh, S. P., Kumar, S., Mathan, S. V., Tomar, M. S., Singh, R. K., Verma, P. K., Kumar, A., Kumar, S., Singh, R. P., & Acharya, A. (2020). Therapeutic Application of Carica papaya Leaf Extract in the Management of Human Diseases. DARU Journal of Pharmaceutical Sciences, 28(2), 735–744. https://doi.org/10.1007/s40199-020-00348-7
Skyler, J. S., Bakris, G. L., Bonifacio, E., Darsow, T., Eckel, R. H., Groop, L., Groop, P. H., Handelsman, Y., Insel, R. A., Mathieu, C., McElvaine, A. T., Palmer, J. P., Pugliese, A., Schatz, D. A., Sosenko, J. M., Wilding, J. P., & Ratner, R. E. (2017). Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis. Diabetes, 66(2), 241–255. https://doi.org/10.2337/db16-0806
Somanah, J., Aruoma, O. I., Gunness, T. K., Kowelssur, S., Dambala, V., Murad, F., Googoolye, K., Daus, D., Indelicato, J., Bourdon, E., & Bahorun, T. (2012). Effects of a Short Term Supplementation of a Fermented Papaya Preparation on Biomarkers of Diabetes Mellitus in a Randomized Mauritian Population. Preventive Medicine, 54 Suppl, S90–S97. https://doi.org/10.1016/j.ypmed.2012.01.014
Somanah, J., Bourdon, E., & Bahorun, T. (2017). Extracts of Mauritian Carica papaya (var. solo) protect SW872 and HepG2 Cells Against Hydrogen Peroxide Induced Oxidative Stress. Journal of Food Science and Technology, 54(7), 1917–1927. https://doi.org/10.1007/s13197-017-2626-4
Somsri, S., & Bussabakornkul, S. (2008). Identification of Certain Papaya Cultivars and Sex Identification in Papaya by DNA Amplification Fingerprinting (DAF). Acta Horticulturae, (787), 197–206. https://doi.org/10.17660/actahortic.2008.787.19
Sosa, V., Moliné, T., Somoza, R., Paciucci, R., Kondoh, H., & LLeonart, M. E. (2013). Oxidative Stress and Cancer: An Overview. Ageing Research Reviews, 12(1), 376–390. https://doi.org/10.1016/j.arr.2012.10.004
Souza, L. M., Ferreira, K. S., Chaves, J. B., & Teixeira, S. L. (2008). L-ascorbic acid, β-Carotene and Lycopene content in Papaya Fruits (Carica papaya) with or without physiological skin freckles. Scientia Agricola, 65(3), 246–250. https://doi.org/10.1590/s0103-90162008000300004
Srivastava, A. K., & Singh, V. K. (2016). Carica papaya- A Herbal Medicine. International Journal of Research Studies in Biosciences, 4(11). https://doi.org/10.20431/2349-0365.0411004
Stahl, W., & Sies, H. (2005). Bioactivity and Protective Effects of Natural Carotenoids. Biochimica Et Biophysica Acta, 1740(2), 101–107. https://doi.org/10.1016/j.bbadis.2004.12.006
Süntar, I., Akkol, E. K., Nahar, L., & Sarker, S. D. (2012). Wound Healing and Antioxidant PROPERTIES: Do they coexist in plants? Free Radicals and Antioxidants, 2(2), 1–7. https://doi.org/10.5530/ax.2012.2.2.1
Syed, H. M., Kunte, S. P., Jadhav, B. A., & Salve, R. V. (2011). Extraction and Characterization of Papaya Seed Oil. Elixir Agriculture 37A, 4102–4105.
Tariq, S. A. (2007). Role of Ascorbic Acid in Scavenging Free Radicals and Lead Toxicity from Biosystems. Molecular Biotechnology, 37(1), 62–65. https://doi.org/10.1007/s12033-007-0045-x
Thomas, K.D., Ajani, B., 1987. Antisickling Agent in an Extract of Unripe Pawpaw Fruit (Carica papaya). Trans. Royal Society of Tropical Medicine and Hygiene 81, 510–511
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free Radicals and Antioxidants in Normal Physiological Functions and Human Disease. The International Journal of Biochemistry & Cell Biology, 39(1), 44–84. https://doi.org/10.1016/j.biocel.2006.07.001
Vij, T., & Prashar, Y. (2015). A review on medicinal properties of Carica papaya Linn. Asian Pacific Journal of Tropical Disease, 5(1), 1–6. https://doi.org/10.1016/s2222-1808(14)60617-4
Wall, M. M. (2006). Ascorbic acid, Vitamin A, and Mineral Composition of Banana (Musa sp.) and papaya (Carica papaya) Cultivars Grown in Hawaii. Journal of Food Composition and Analysis, 19(5), 434–445. https://doi.org/10.1016/j.jfca.2006.01.002
Waly, M. I., Al-Rawahi, A. S., Al Riyami, M., Al-Kindi, M. A., Al-Issaei, H. K., Farooq, S. A., Al-Alawi, A., & Rahman, M. S. (2014). Amelioration of Azoxymethane Induced-Carcinogenesis by Reducing Oxidative Stress in Rat Colon by Natural Extracts. BMC Complementary and Alternative Medicine, 14, 60. https://doi.org/10.1186/1472-6882-14-60
Yahia, E. M., & Ornelas-Paz, J. de. (2010). Chemistry, Stability, and Biological Actions of Carotenoids. Fruit and Vegetable Phytochemicals, 177–222. https://doi.org/10.1002/9780813809397.ch7
Yogiraj, V., Goyal, P. K., Chauhan, C. S., Goyal, A., & Vyas, B. (2015). Carica papaya Linn: An Overview. International Journal of Herbal Medicine, 2(5), 01–08.
You, Z., Sun, J., Xie, F., Chen, Z., Zhang, S., Chen, H., Liu, F., Li, L., Chen, G., Song, Y., Xuan, Y., Zheng, G., & Xin, Y. (2017). Modulatory Effect of Fermented Papaya Extracts on Mammary Gland Hyperplasia Induced by Estrogen and Progestin in Female Rats. Oxidative Medicine and Cellular Longevity, 2017, 8235069. https://doi.org/10.1155/2017/8235069
Zanna, M., Shettima, A.Y., Daja, A., (2017). Antidiarrhoeal effects of aqueous leave extract of Carica papaya in wistar strain albino rats. Journal of Multidisciplinary Engineering, Science and Technology. 9, 2017
Zhang, J., Mori, A., Chen, Q., & Zhao, B. (2006). Fermented Papaya Preparation Attenuates Beta-Amyloid Precursor Protein: Beta-Amyloid-Mediated Copper Neurotoxicity in Beta-Amyloid Precursor Protein and Beta-Amyloid Precursor Protein Swedish Mutation Overexpressing SH-SY5Y Cells. Neuroscience, 143(1), 63–72. https://doi.org/10.1016/j.neuroscience.2006.07.023
Zhao, Y., & Zhao, B. (2013). Oxidative Stress and the Pathogenesis of Alzheimer's Disease. Oxidative Medicine and Cellular Longevity, 2013, 316523. https://doi.org/10.1155/2013/316523
Zhou, L., Christopher, D. A., & Paull, R. E. (2000). Defoliation and Fruit Removal Effects on Papaya Fruit Production, Sugar Accumulation, and Sucrose Metabolism. Journal of the American Society for Horticultural Science, 125(5), 644–652. https://doi.org/10.21273/jashs.125.5.644
Downloads
Published
Issue
Section
Categories
License
Copyright (c) 2024 R AHMAD, R WALEED, MZ HAIDER (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.